Risk Factors for Colorectal Cancer

In this review, modifiable and non-modifiable risk factors that contribute to development of colorectal cancer are discussed, exploring the role of genetics and heritable colon cancer syndromes along with medical comorbidities that influence risk. Socioeconomic factors that contribute to colorectal cancer risk are explored along with various health-related behavioral patterns such as obesity, smoking, and diet. Recent data suggesting changes in the incidence of colorectal cancer in the last decade is also reviewed. The rationale for a long-term population-based exploration of these issues is laid out to identify areas in which intervention can promote healthy behaviors, avoid disease, and optimize treatments.